Chemical Modification of Lys-6 in Phospolipase A2 from Naja melanoleuca Snake Venom
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چکیده
منابع مشابه
Snake venom toxins. The amino acid sequences of toxins b and d from Naja melanoleuca venom.
Two toxins have been isolated from the venom of the Forest cobra (Naja melanoleuca) and their amino acid sequences elucidated. Toxin b, a 71 amino acid residue molecule, is devoid of methionine and resembles toxin (x from Naja nivea venom both immunochemically and in amino acid sequence. Toxin d consists of 61 amino acid residues with alanine, phenylalanine, and leucine totally absent. Toxin d ...
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Health threat due to snake bite is one of the most ignored areas of active research vis-à-vis other domains of human healthcare studies. Fatalities due to snake bite are a major health threat affecting the lives of thousands of people every year in many developing countries. The prevalence of mortality caused by snake bite is taken as one of the serious challenges to solve the problem. The obje...
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Phospholipases A2 (PLA2) are the most lethal and noxious component of Naja naja karachiensis venom. They are engaged to induce severe toxicities after their penetration in victims. Present study was designed to highlight hydrolytic actions of PLA. in an egg yolk mixture and to encounter their deleterious effects via medicinal plants of Pakistan. PLA2 were found to produce free fatty acids in a ...
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One small-scale double emulsion technique for incorporation of Naja- Naja oxiana venom into Poly (lactide-co-glycolide) (PLGA) microspheres were developed and optimized. The effects of high speed homogenization on the double emulsion stability, microsphere size, entrapment efficiency and In vitro release of venom were studied. A stable double emulsion was verified by homogenization method. Slow...
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The myocardial effect of snake venoms is considered as one of the most common pathogenesis in many cases of snake envenomation. This study was under taken to investigate the effects of snake (Naja naja oxiana) venom on cardiac function in experimental animals. The blood samples from all the rabbits were collected before venom injection and then 140 µg/kg venom of snake (Naja naja oxiana) was in...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1983
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1983.tb07344.x